乔宏志

发布者:花文婷发布时间:2022-09-27浏览次数:10


职称:副教授   E-mail:qiaohz@njucm.edu.cn      主要研究方向:1)新型药物制剂设计;(2)结构中药学

 

个人简介

       乔宏志,副教授、硕士生导师。“全国高校黄大年式教师团队”骨干成员,中国科协青年人才托举工程、江苏省“333”工程中青年科技带头人、江苏省六大人才高峰高层次人才、江苏省青蓝工程优秀青年骨干教师等项目入选者。提出结构中药学理论和研究范式(中国中药杂志,2021,封面文章),在中药学领域构建起聚集体层次的新兴方向。先后主持国家自然科学基金、江苏省自然科学基金等项目8项;在Adv Drug Deliv RevBiomaterialsChem Sci等期刊发表学术论文50余篇,他引1000余次,部分文章获封面、HighlightNat Rev Nephrol等正面报道和推荐,发明专利4项。获江苏省中医药科技一等奖。兼任中华中医药学会青委会委员、世界中医药学会联合会中医药抗病毒研究专委会常务理事等;担任Adv Drug Deliv Rev专刊主编、Acta Pharm Sin BAcupunct Herb Med等刊物青年编委。主持江苏省高等教育教改研究课题、中药九年制本博连读专业新兴交叉融合课程“结构中药学”,主讲工业药剂学等专业核心课程,参编行业规划教材多部。指导国家级大学生创新训练重点项目4项,获推参展全国大学生创新创业年会;指导研究生创新工程项目8项,指导优秀本硕论文多部;指导中国国际互联网+”大学生创新创业大赛银奖、省一等奖两次并获优秀指导教师,取得校历史性突破。

 

承担的主要科研项目

 1) 国家自然科学基金,81503259,基于药载同源构建肿瘤深层穿透的茶多酚-蜂毒肽纳米递送系统,2016.01.01-2018.12.3118主持

2) 江苏省自然科学基金,BK20151002,高穿透蜂毒肽一体两药自纳米化系统的构建及其抗肿瘤研究,2015.07.01-2018.06.3020主持

3) 中国博士后科学基金第59批面上资助项目,2016M591813,针对肿瘤异靶区递药的ATP响应型配位组装体系构建,2016.1-2017.125万,主持

4) 江苏省博士后科研资助计划项目,1601238C,基于配位组装的ATP响应型抗肿瘤联合递药系统构建,2016.1-2017.121万,主持

5) 国家重点基础研究发展计划(973计划)项目,2015CB856300,靶向线粒体代谢的分子探测与过程调控,1600万,参与

6) 南京中医药大学中药学优势学科杰出人才培育项目,仿生药物传输体系的架构与功能,2017.5-2020.530万,主持

7) 中国科协青年人才托举工程项目,中药源性功能辅料的发现、改造与应用研究,2017QNRC0012017-2019年,45,主持

8) 中央本级重大增减支项目,名贵中药资源可持续利用能力建设子课题,2060302-1907-042019.9-2021.1240万,主持

9) 江苏省高等学校自然科学研究重大项目,鲜地黄免疫活性单元的解析及其抗肿瘤联合治疗的研究,20KJA360004202010-20239月,30,主持

 

代表性论文

1) Qiao Hongzhi#, Sun Minjie#, Su Zhigui, Xie Ying, Chen Minglei, Zong Li*, Gao Yahan, Li Huipeng, Qi Jianping, Zhao Qun, Gu Xiaochen, Ping Qineng*. Kidney-specific drug delivery system for renal fibrosis based on coordination-driven assembly of catechol-derived chitosan. Biomaterials, 2014, 35(25):7157-7171.

2) Qiao Hongzhi#, Fang Dong#, Chen Jing, Sun Yuan, Kang Chen, Di Liuqing*, Li Junsong, Chen Zhipeng, Chen Jun, Gao Yahan*. Orally delivered polycurcumin responsive to bacterial reduction for targeted therapy of inflammatory bowel disease. Drug Deliv, 2017, 24(1): 233-242.

3) Qiao Hongzhi#, Fang Dong#, Zhang Lei, Gu Xiaochen, Lu Yin, Sun Minjie, Sun Chunmeng, Ping Qineng, Li Junsong, Chen Zhipeng, Chen Jun, Hu Lihong, Di Liuqing*. Nanostructured Peptidotoxins as Natural Pro-Oxidants Induced Cancer Cell Death via Amplification of Oxidative Stress. ACS Appl Mater Interfaces, 2018, 10(5): 4569-4581.

4) Lina Gao#, Lei Zhang#, Xuyu Zhu, Jing Chen, Meng Zhao, Simin Li, Chengli Yu, Lihong Hu*, Hongzhi Qiao*, Zijian Guo. Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy, J Mater Chem B, 2020, 8, 4841-4845.

5) Hongzhi Qiao#, *, Lei Zhang#, Dong Fang, Zhenzhu Zhu, Weijiang He, Lihong Hu, Liuqing Di, Zijian Guo, Xiaoyong Wang*; Surmounting tumor resistance to metallodrugs by co-loading metal complex and siRNA in nanoparticles, Chem Sci, 2021, 12(12):4547-4556.

6) Lei Zhang#, Fengjun He#, Lina Gao, Minghui Cong, Juan Sun, Jialu Xu, Yutong Wang, Yang Hu, Sajid Asghar, Lihong Hu*, Hongzhi Qiao*. Engineering exosome-like nanovesicles derived from Asparagus cochinchinensis can inhibit the proliferation of hepatocellular carcinoma cells with better safety profile, Int J Nanomedicine, 2021, 16:1575-1586.

7) Lina Gao, Lei Zhang, Fengjun He, Jing Chen, Meng Zhao, Simin Li, Hao Wu, Yumeng Liu, Yinan Zhang, Qineng Ping, Lihong Hu*, Hongzhi Qiao*. Surfactant assisted rapid-release liposomal strategies enhance the antitumor efficiency of bufalin derivative and reduce cardiotoxicity, Int J Nanomedicine, 2021, 16:3581-3598.

8) Jing Zhang#, Kaili Hu#, Liuqing Di, Penglong Wang, Zhidong Liu, Jinming Zhang, Pengfei Yue, Wantong Song, Jingwei Zhang, Tongkai Chen, Zuhua Wang, Yongtai Zhang, Xiaoying Wang, Changyou Zhan, Yung-Chi Cheng, Xiang Li, Quan Li, Jing-Yu Fan, Youqing Shen*, Jing-Yan Han*, Hongzhi Qiao*. Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health, Adv Drug Deliv Rev, 2021, 178: 113964.

9) Chenglin Song#, Chenxi Yang#, Siwei Meng, Manru Li, Xiao Wang, Yaoxuan Zhu, Lingdong Kong, Wen Lv*, Hongzhi Qiao*, Yang Sun*, Deciphering the mechanism of Fang-Ji-Di-Huang-Decoction in ameliorating psoriasis-like skin inflammation via the inhibition of IL-23/Th17 cell axis, J Ethnopharmacol, 2021, 281: 114571.

10) Minghui Cong#, Shenyu Tan#, Simin Li, Lina Gao, Luqi Huang*, Huang-Ge Zhang*, Hongzhi Qiao*. Technology insight: plant-derived vesicles—how far from the clinical biotherapeutics and therapeutic drug carriers? Adv Drug Deliv Rev, 2022, 182:114108.

 





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