题目：基于中药有效成分的靶标发现
主讲人：寇俊萍教授
时间：2013年12月24日（星期二）10:00 am
地点：仙林校区B14-201
寇俊萍，博士，中西医结合基础（药学），教授，博士生导师, 中国药科大学中药复方研究室副主任。国家自然科学基金医学部中医中药学科同行评议专家，科技部国际科技合作计划评价专家，教育部科技成果与奖励评审专家，教育部新世纪优秀人才，南京市科技评审专家，中国实验方剂学杂志副主任编委,江苏省药理学会理事。
学习、工作经历
1989.9-1994.6，中国药科大学，中药药理专业学士
1994.8-2000.6，中国药科大学中药复方研究室见习研究员
1996.9-2000.6，中国药科大学，中药学专业在职硕士, 导师严永清教授
2000.6-2005.6，中国药科大学，助理研究员
2001.9-2005.6，南京大学，生理学专业在职博士, 导师徐强教授
2005.6-2009.6，中国药科大学，副研究员(破格晋升)
2006.10 中国药科大学，中西医结合基础（药学）硕士生导师
2007.10-2008.10，日本岐阜药科大学，访问学者
2009.6-，中国药科大学，教授(破格晋升)
2011.7- 中国药科大学，中西医结合基础（药学）博士生导师
近期代表性论文及成果等
已发表论文108篇，其中通讯作者24篇，第1作者30篇，SCI收录34篇；已获授权专利17项，公开5项，主要代表性论文：
[1]Ruscogenin reducescerebral ischemic injury via NF-κB-mediated inflammatory pathway in the mousemodel of experimental stroke. Eur JPharmacol. 2013;714(1-3):303-311
[2]Diosgenindown-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lunginjury induced by lipopolysaccharide in mice. IntImmunopharmacol. 2013,15(2):240-245
[3]Chemical and microbial semi-synthesis oftetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity. Bioorg& Med Chem, 2013,21(1):62–69
[4]Diosgenin ameliorates palmitate- inducedendothelial dysfunction and insulin resistance via blocking IKKb and IRS-1 pathways. Atherosclerosis,2012,223(2): 350-358
[5]Safety evaluation of steroidal saponin DT-13isolated from the tuber of Liriope muscari (Decne.) Baily. Food ChemToxicol 2011, 49 (9): 2243-2251.
[6]Ginsenoside Rg1 protects against hydrogenperoxide-induced cell death in PC12 cells via inhibiting NF-kB activation. Neurochem Int 2011,58(1):119-125
[7]Ruscogenin mainly inhibits nuclear factor-κBbut not Akt and mitogen-activated protein kinase signaling pathways in humanumbilical vein endothelial cells. J Pharmacol Sci 2010,113(4),409 – 413
[8]Hypothesis on the principle of Danggui-Shaoyao-San (DSS) for treating different diseases via the histamine H1 Receptorpathway. Modern Tradit Chin Med Mater Med, 2010, 12(3): 325–330
[9]The effects of twelve representative?avonoids on tissue factor expression in human monocytes: Structure-activityrelationships. Thromb Res. 2009, 124(6): 714–720.
[10]Neuroprotectiveeffects of the aqueous extract of Chinese medicine Danggui-Shaoyao -san on agedmice. J Ethnopharmacol. 2005, 97:313-318.
[11]Inhibitoryeffect of ethanol extract from Radix Ophiopogonis japonicus on venous thrombosislinked with its endothelium-protective and anti-adhesive activities. VascPharmacol. 2005, 43 (3): 157 – 163.
